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Genetics of Scoliosis: What We Know So Far

Genetics of Scoliosis: What We Know So Far

If you’re like most scoliosis patients, the idea of genetic factors playing a part in your scoliosis diagnosis is unsettling to say the least. The idea of a genetic predisposition for adolescent idiopathic scoliosis (AIS), much like other disorders such as muscular dystrophy and heart disease, can be a scary prospect. But the good news is that genetics only play a role in determining if you’re at risk of getting scoliosis- not whether or not you’ll actually develop it.


That said, according to the most recent genetic research, there are certain genes that can cause scoliosis if present in specific combinations. And some defective genes have been found to increase susceptibility for scoliosis in the human genome. In this blog, we shall unravel the mystery of whether or not scoliosis is the result of genetic defects and what factors do play a role in development of adolescent idiopathic scoliosis if any. We shall also cover treatment options available currently and how early detection is crucial.


How Do You Get or Develop Scoliosis?

In many cases, adolescent idiopathic scoliosis is caused by a genetic mutation (DNA) of the scoliosis related genes. This gene provides instructions for the development of the scoliosis curve and can be inherited.


There is clear evidence inherited genetic mutations are believed to be a major factor in scoliosis. Scoliosis can result from congenital or acquired spinal deformities. These types of spinal deformities result in abnormal curvature of the spine, which can cause chronic pain and difficulty walking. Some medical conditions such as cerebral palsy, spinal cord tethering, and muscular dystrophy can also lead to scoliosis. So it's important to get checked for scoliosis as soon as a problem develops so that any underlying causes can be addressed quickly and effectively.


What Does Hereditary Mean?

Scoliosis is a condition in which the spine curves to one side. It can be caused by trauma, genetics, or other factors. In many cases, the cause of scoliosis is known and can be treated. However, in other cases with a family history of the condition, scoliosis may be hereditary and DNA testing may be able to identify any genetic markers that may be linked to the condition. Identifying these markers can allow doctors to develop better treatment plans for those with scoliosis. Genome testing can help patients and their families understand the risk of scoliosis susceptibility and whether treatments will be effective. By identifying any genetic risk factors, patients can make informed decisions about their treatment options and reduce the risk of serious complications down the line.


An In-Depth Look into Scoliosis Causes


Are There Genetic Scoliosis Causes?

Scoliosis is a condition that causes the spine to curve abnormally, resulting in back pain and other symptoms. Genetic scoliosis is believed to be caused by abnormalities in certain genes, although the exact mechanisms are still being studied. Family history can be a major risk factor for genetic scoliosis, and certain ethnicities are more likely to suffer from this condition. Diagnosis of genetic scoliosis usually involves a combination of medical imaging tests, physical examinations, and genome testing. Treatment of scoliosis often includes scoliosis exercises, bracing, or surgery, depending on the size of the curve.


Is Scoliosis Hereditary?

Scoliosis is a condition in which the spinal column curves to the side. Researchers have identified genetic mutations in the genome associated with an increased risk of developing scoliosis. Studies have also identified certain genes that are responsible for the development of scoliosis. While genetics appear to be involved in some scoliosis cases, environmental factors can also contribute to the condition. Family inheritance is an important factor to consider when determining if someone is at risk of developing scoliosis. If a family member (especially first degree relatives) has the condition or has been diagnosed with it recently, it may help with the decision about whether or not to undergo DNA testing to determine inheritance.


Is Scoliosis Environmental?

Scoliosis is a neuro-hormonal disorder that causes the spine to curve abnormally. The exact causes of scoliosis are unknown, but scientists believe genetics play a role in its development. Research has shown that scoliosis may be caused by a combination of genetic and environmental factors. Genetic mutations and changes can affect the body's ability to regulate growth and development of the spine. Environmental risks such as lifestyle, nutrition, and stress can influence the expression of genes that are related to scoliosis.


Overall, it is still unclear why scoliosis occurs and how it can be prevented or treated. However, there are steps people can take to reduce the risk of developing the disease, including maintaining a healthy weight and exercising regularly. Additionally, it is important to seek treatment as soon as possible to help manage symptoms and improve quality of life.


More Factors Lead to Curve Progression

Scoliosis is a condition characterized by a curved back. It is a complex disease with many possible influencing factors, including genetic associations. A recent study identified 28 gene variants associated with scoliosis. These variants are known for their potential to influence a person's risk of developing scoliosis. However, most cases of scoliosis are idiopathic, meaning there is no known underlying cause of the condition. Genetics may be the cause of scoliosis in some cases. Other factors that can lead to progressive curves include posture and hormone imbalance. Besides genetics and other factors, poor posture and muscle weakness can also play a role in scoliosis progression. In addition to genetic factors and other external factors, a patient’s health care team must work together to properly diagnose and treat scoliosis.


Scoliosis runs in families.

In the past, scoliosis was believed to be caused by weak bones and a spinal curve. It is now known that scoliosis is a genetic condition. In most cases of scoliosis, the genes responsible for the spinal curvature are inherited from one or both of the parents. The genes involved in scoliosis development have been identified through studies of patients with the condition and from studies of families with a history of scoliosis. Interestingly, it is possible for one identical twin to develop scoliosis and not the other.


There are treatments for scoliosis based on genetic factors, but it is vital that the underlying cause of the condition is treated first. This may include medications, bracing, surgery, or a combination of these methods. Patients with scoliosis should undergo genome testing if their family history indicates a high risk for developing the condition.


Early diagnosis is key.

As detection of idiopathic scoliosis has increased in frequency, so does the need for a genetic diagnosis. Identifying the genetic cause of scoliosis is a difficult task, but progress is being made. Scoliosis is known to be an inherited condition, and the genes involved are still unknown. But DNA testing can help diagnose scoliosis and predict the progression of the curves in patients. Research has shown a link between scoliosis and several other genetic disorders, such as Marfan Syndrome and Ehlers-Danlos Syndrome. Thus, DNA testing can provide insight into a patient's scoliosis history and potential risk factors during periods of rapid growth.


The Best Scoliosis Treatment Treats the WHOLE Scoliosis condition

Scoliosis is a complex condition with multiple causes, including genetics. A genetic predisposition to developing scoliosis exists, but factors such as environmental factors and other disease processes also play a role in the development of the condition.

Early diagnosis and treatment of scoliosis are crucial to managing the progression, symptoms, and effects of the condition. In some severe cases, surgery may be recommended. Back bracing or physical therapy may help reduce spine curves and manage pain.  Highly targeted nutrient therapies have been developed to help scoliosis patients overcome these genetic defects. However, no single treatment is guaranteed to help alleviate scoliosis symptoms or reverse the disease process. As a result, research is ongoing to better understand the genetic basis of scoliosis and develop more effective treatments for this condition.

Only Testing & Nutrient Therapy for Scoliosis

Scoliosis is a serious condition that can cause pain and impairment. It can be genetic or environmental in nature. Early diagnosis is crucial to preventing further progression of the condition. DNA testing can reveal specific mutations that may be causing scoliosis. Nutrient therapy, such as dietary supplementation, has been shown to help reduce the severity of scoliosis. It is also important to note that not all scoliosis cases are caused by genetics and some cases have no known cause.


While genetics play a role in the development of scoliosis, it is not always possible to identify a genetic cause. In these cases, environmental factors must also be considered. To prevent scoliosis from progressing, patients are often encouraged to engage in physical activities that can strengthen the muscles around the spine and improve posture. In addition, patients may be recommended to wear a back brace during physical activity to help support the spine.

Reflexive Retraining Resets Your Postural Memory!

Scoliosis is a complex condition that is believed to have genetic and environmental factors. Recent studies have identified several genes associated with scoliosis, but the exact causes of this condition are still not fully understood. Early diagnosis of scoliosis is critical in managing the condition, as the condition can worsen over time. Reflexive retraining rehabilitation can help reduce the effects of scoliosis by helping patients improve their posture and reduce pain. This type of rehabilitation involves practicing corrective exercises that can help restore normal posture and reduce physical strain on the spine. By resetting your postural memory, reflexive retraining can help improve your posture and ease pain related to scoliosis.



Frequently Asked Questions


What is the current research on the genetics of scoliosis?

Recent research has shown that scoliosis is a complex disorder and likely has a genetic component. Studies have identified gene variations associated with scoliosis, particularly in the genes related to connective tissue development and cell signaling. It is believed that scoliosis may be caused by an interaction between multiple genes and environmental factors.

At the same time, further research is needed to better understand the genetics of scoliosis and how it can be prevented or treated. For example, research is currently being conducted on ways to modify gene expression or use gene therapy to effectively treat scoliosis patients.

By continuing to explore the genetic basis of scoliosis, researchers hope to gain more insight into this condition and develop more effective treatments for those affected by it.


Are there any genetic tests available to diagnose scoliosis?

Yes, genetic tests are available to diagnose scoliosis through "Back Genius™" providers. These tests look for mutations in genes, not a single gene, associated with the condition. Currently, DNA testing is not routinely used to diagnose scoliosis as the condition can be diagnosed through physical examinations and medical imaging. However, DNA testing can help confirm a diagnosis and inform future treatment decisions. For example, genetic testing can help identify the cause of scoliosis in cases of idiopathic scoliosis where the cause is unknown. It may also provide insight into the risk for curve worsening, as well as potential treatment options.


Are there any treatments or therapies that are specific to genetically caused scoliosis?

Yes, there are treatments and therapies that are specific to genetically caused scoliosis. The first step is to have genetic testing done to determine whether scoliosis is caused by a genetic mutation. For mild scoliosis (cobb angle less than 25 degrees), physical therapy and bracing may be recommended to help manage the pain and deformity of scoliosis. Severe cases may require surgery.


There are also some promising new therapies that target the underlying genetic cause of scoliosis, such as scoliosis-specific nutrient therapies personalized for each patient's genetic pathways and needs. These therapies are still in the research phase, but they offer the potential of preventing progression of scoliosis or even reversing it completely.


What are some lifestyle changes that may help people with genetically caused scoliosis?

People with scoliosis due to genetic causes can make a few lifestyle changes to help manage their condition.

Firstly, it is important to exercise regularly in order to strengthen the muscles and improve posture. Stretching and low-impact activities are especially beneficial for people with scoliosis as they promote flexibility, help reduce pain and discomfort, and even slow down progression of the curvature.

In addition, it is also beneficial to wear supportive braces or clothing when necessary. This can provide additional support while sitting or standing for long periods of time.

Finally, it is important to maintain a balanced diet rich in calcium and vitamin D. These nutrients play an important role in supporting healthy bones, which can reduce the severity of the curvature associated with scoliosis.